What is chlorine dioxide?

Chlorine dioxide (ClO2) is a gas with strong oxidizing properties. An "oxidizing agent" removes electrons from reactive molecules. By this process, ClO2 quickly neutralizes and eliminates odors, acts as a bleach, and also breaks the cell wall of microorganisms. ClO2's action is rapid on most microorganisms and is unique in its ability to kill bacteria, virus, fungus and spores. Chlorine dioxide was first discovered in 1811 by Humphrey Davy. Today, ClO2 is primarily used as a disinfectant for municipal water subplies, especially those with odor and taste problems. It is also extensively used as a bleaching agent in the pulp and paper industry instead of chlorine, since chlorine was found to produce carcinogens. Some newer applications for ClO2 include the disinfection of fruit, vegetables, meat and seafood, the treatment of medical waste, and as a sanitizer in the canning industry. Until recently, however, chlorine dioxide was not available for use on a "small-scale" or for topical application because the gas must be generated at the point of use and could not be easily transported.

What is the "DioxiCare® System"?

The DioxiCare® System is Frontier Pharmaceutical's proprietary method of generating chlorine dioxide for small-scale application. The gas is captured in a liquid or gel at specific concentrations. The activated product is immediately available for use. Frontier's inventive 2-part system enables the user to produce the active ingredient on demand, and at an acidity that is suitable for use on the body. This is in contrast to other chlorine dioxide systems which require lower, more irritating acidity levels, and long reaction times to achieve usable concentrations. The DioxiCare System actually produces a chlorous acid/chlorine dioxide complex, which increases its efficacy. Frontier's versatile products are available in liquid, gel and paste dosage forms.

Is chlorine dioxide safe?

The Niagara Falls New York water treatment plant first used chlorine dioxide for drinking water disinfection in 1944. Currently, there are approximately 400 - 500 water treatment plants in the United States and over 1000 in Europe utilizing ClO2 to purify municipal drinking water systems. Numerous studies have shown chlorine dioxide, when used at the appropriate concentrations, has no adverse health effects, either by skin contact or ingestion.

What's the difference between chlorine and chlorine dioxide?

While chlorine dioxide (ClO2) has chlorine in its name, chlorine dioxide's chemistry is different from that of chlorine. Unlike the more common chlorine, chlorine dioxide, at appropriate concentrations, is non-mutagenic, non-carcinogenic, and relatively non-irritating. When ClO2 is added to water, it dissolves without ionizing. Or more specifically, when exposed to water, ClO2 does not release a chlorine atom to form hydrochloric acid as does chlorine, nor does it combine with organics to form chlorinated hydrocarbons, which are carcinogenic.

One atom can make all the difference --- just as hydrogen is an explosive gas, but when combined with oxygen becomes dihydrogen oxide - commonly known as water (H2O).

What is the difference between "Active" chlorine dioxide and "Stabilized" chlorine dioxide?

Stabilized chlorine dioxide is a misleading term that is unfortunately in widespread use. There are only trace amounts of chlorine dioxide in "stabilized chlorine dioxide" products. The correct description is "stabilized chlorite." The chlorite is stabilized with a buffer and peroxide at a pH of about 7. In order to generate a meaningful level of chlorine dioxide in a stabilized chlorite product, either chlorine or a strong acid must be added. Though chlorite, or stabilized chlorite, is also an oxidizing agent, it is not nearly as powerful as chlorine dioxide. Chlorine dioxide, unlike chlorite, is a gas that must be generated at the time of application by mixing 2 separate parts. With the DioxiCare(R) System, the term "active" chlorine dioxide is used to distinguish between the two systems.

Why two different parts?

Frontier's DioxiCare(R) System is a patented formulation that speeds the formation of ClO2 and chlorous acid, making the active ingredients immediately available for use, unlike any other ClO2 products. Because ClO2 is a gas and "unstable", meaning it slowly dissipates with time, the two components of the DioxiCare System are mixed just prior to use in order to assure freshness of the preparation

How long will DioxiCare® freshen my breath?

Halimeter studies have shown that DioxiRinse(TM) Mouthwash completely eliminates bad breath for 3 - 4 hours after use, even with repeated challenges of cysteine (substance utilized by bacteria to form volatile sulfur compounds). In a second stringent clinical study, the breath of 15 patients with chronic halitosis was evaluated the day following a one-week regimen of rinsing with DioxiRinse Mouthwash. Even tested the day after mouth rinsing, their odor scores were half the pretreatment value. This was measured by human judges and by halimeter readings. Furthermore, after one rinse with DioxiRinse, bacterial load was reduced by 60%.

Whom can I speak with for more information?

For further information, email customerservice@frontierpharm.com or call toll free at 1-800-767-3486 weekdays from 9:00 am to 5:00 p.m. EST.

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